Mammary carcinoma, non-Hodgkin's lymphoma, primary liver cell carcinoma, ovarian carcinoma 14 mg/m2 BSA as initial dose for 1st cycle. Repeat after 21 days. Acute leukemia 10-12 mg/m2 for 5 consecutive days.
Contraindications
Apply w/ caution to patients w/ pancytopenia or severe infections, severe hepatic &/or renal insufficiency, severe heart disease & those previously treated w/ anthracyclines &/or irradiated on mediastinum. Pregnancy & lactation.
Special Precautions
Monitor hematological blood parameters before each application as well as at least once during each treatment cycle. Monitor heart function after cumulative dose of >160 mg/m2 BSA (140 mg/m2 in risky patients) has been reached.
Adverse Reactions
Bone marrow depression, nausea, vomiting, alopecia, transient ECG alteration, acute arrhythmia, reduced left ventricular output, cardiac insufficiency, blue-green urine coloration.
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